A revolutionary drug combination has been discovered with the potential to cure diabetes, according to a research team from Mount Sinai and City of Hope. The treatment, involving harmine and a GLP1 receptor agonist found in Ozempic, resulted in a sevenfold increase in pancreatic beta cells when tested on mice. This remarkable increase led to the reversal and eventual eradication of diabetes symptoms.

Dr. Adolfo Garcia-Ocaña, corresponding author of the study, emphasized the significance of this breakthrough: “This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo. This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The innovative treatment was applied to human beta cells injected into mice, leading to a sevenfold increase in beta cells within three months. Moreover, one month after discontinuing the treatment, diabetes symptoms were no longer detectable.

Previous attempts at similar treatments involved coaxing stem cells into becoming human pancreas beta cells in vitro and then transplanting them into patients with diabetes. However, these methods were both costly and time-consuming. This new drug offers a more efficient and affordable alternative.

Harmine alone has recently completed phase 1 clinical trials in humans to assess its safety and tolerability. Meanwhile, inhibitors of the enzyme DYRK1A are yet to be tested. The complete study can be found in the journal Science Translational Medicine.

In related news, the U.S. government has taken measures to make insulin more affordable for diabetes patients. As detailed in this article, the monthly cost of insulin has been reduced to $35, marking a significant decrease from previous prices.

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Source: Good News Network